Paediatric formulations

Carvedilol stability in paediatric oral liquid formulations

front matter & 2009 a.2010.01.002 author. : diegochiappetta@y Abstract Objective: Two carvedilol aqueous solutions and one carvedilol aqueous suspension for paediatric oral use (1mg/ml) were studied to determine their stability. Method: All samples were stored at 4, 25 and 401C. Carvedilol content of each of the three formulations was tested using high performance liquid chromatography (HPLC). ...

LC–UV/MS quality analytics of paediatric artemether formulations

A highly selective and stability-indicating HPLC-method, combined with appropriate sample preparation steps, is developed for β-artemether assay and profiling of related impurities, including possible degradants, in a complex powder for oral suspension. Following HPLC conditions allowed the required selectivity: a Prevail organic acid (OA) column (250 mm×4.6 mm, 5 μm), flow rate set at 1.5 mL/m...

Microbiological Quality of Paediatric Oral Liquid Drug Formulations during Consumption

This preliminary study was conducted to evaluate the microbiological quality of paediatric oral liquid drug formulations during consumption. Paracetamol, Salbutamol, Cephalexin, Amoxicillin and Lactulose are few oral liquid medicines prescribed in Sri Lanka. These oral liquid medicines are at a greater risk of microbial contamination during consumption. This can lead to co-infection in paediatr...

Challenges in the Procurement and Development of Paediatric Antiretroviral Formulations

Development and stability assessment of liquid paediatric formulations containing sildenafil citrate

The purpose of this study is to develop and improve oral liquids formulations of sildenafil citrate for paediatric use. Four different formulations were developed, which are as follows: two aqueous solutions of sildenafil citrate (2.5 mg/mL), with or without preservatives, and two other solutions of sildenafil in simple syrup (1.25 mg/mL), with or without preservatives. All of the formulations ...